Raymond "Red" Reddington, one of the FBI's most wanted fugitives, surrenders in person at FBI Headquarters in Washington, D.C. He claims that he and the FBI have the same interests: bringing down dangerous criminals and terrorists. In the last two decades, he's made a list of criminals and terrorists that matter the most but the FBI cannot find because it does not know they exist. Reddington calls this "The Blacklist". Reddington will co-operate, but insists that he will speak only to Elizabeth Keen, a rookie FBI profiler.

Robyn McCall, an enigmatic former CIA operative with a mysterious background, uses her extensive skills to help those with nowhere else to turn.

The detectives of the Organized Crime Control Bureau work to dismantle New York City's most vicious and violent illegal enterprises.

Loosely based on infamous crime boss Bumpy Johnson, who in the early 1960s returned from ten years in prison to find the neighborhood he once ruled in shambles. With the streets controlled by the Italian mob, Bumpy attempts to regain his piece of Harlem.

When by-the-book FBI Special Agent Bill Goodman is loaned out to a clandestine CIA/FBI task force, he finds himself teamed up with secretive and roguish CIA case officer Colin Glass. Together they work covert operations in New York, uncovering international plots, terrorist cells, and geopolitical secrets.

Neil is so consumed by emotional baggage, it bleeds into every aspect of his life. He's meek, timid, and always the first to apologize. Not ideal for his job as an NYPD parking cop.

As community college professor Peter Gottlieb's life spirals out of control, a strange friendship blossoms with one of his students, Sabrina Carbonowitz. When Sabrina goes missing, Peter is pinned for the whole thing.

After her spaceship crash-lands in the ocean, a woman struggles to understand the reason behind the disappearance of her fellow astronauts.