In the back country of South Africa, black minister Stephen Kumalo journeys to the city to search for his missing son, only to find his people living in squalor and his son a criminal. Reverend Misimangu is a young South African clergyman who helps find his missing son-turned-thief and sister-turned-prostitute in the slums of Johannesburg.

Inspan is dedicated to tough pioneers, who along dangerous roads - with courage and strength - developed the vital transport routes for a young and growing country - the transport riders.