Inspired by actual cases and experiences, Numb3rs depicts the confluence of police work and mathematics in solving crime as an FBI agent recruits his mathematical genius brother to help solve a wide range of challenging crimes in Los Angeles from a very different perspective.

All hope is lost for Michael to keep his wife alive when Susan decides she's done fighting cancer and ends her chemotherapy treatments. That is until an old salesman offers him a mysterious box. The box can extend Susan's life using the memories embedded in the walls of their house. But Michael soon finds out that using the box comes with severe consequences.