In cases ripped from the headlines, police investigate serious and often deadly crimes, weighing the evidence and questioning the suspects until someone is taken into custody. The district attorney's office then builds a case to convict the perpetrator by proving the person guilty beyond a reasonable doubt. Working together, these expert teams navigate all sides of the complex criminal justice system to make New York a safer place.

Raymond "Red" Reddington, one of the FBI's most wanted fugitives, surrenders in person at FBI Headquarters in Washington, D.C. He claims that he and the FBI have the same interests: bringing down dangerous criminals and terrorists. In the last two decades, he's made a list of criminals and terrorists that matter the most but the FBI cannot find because it does not know they exist. Reddington calls this "The Blacklist". Reddington will co-operate, but insists that he will speak only to Elizabeth Keen, a rookie FBI profiler.

The Fugitive Task Force relentlessly tracks and captures the notorious criminals on the Bureau's Most Wanted list. Seasoned agents oversee the highly skilled team that functions as a mobile undercover unit that is always out in the field, pursuing those who are most desperate to elude justice.

A detective who lost everything that he loves. A gang member who was a product of the school to prison pipeline and seeks redemption from his past. Two men from different sides of the law set out to take revenge on a common enemy when they unknowingly run into each other. They embark on a road trip for revenge challenging the idea of forgiveness once realizing the other is not who they seem to be.

After a fight with his girlfriend, a man takes a "relationship pill" that sends him on a journey down Route 66.

A team of thieves regroup at a rural cabin after a diamond heist goes bad, resulting in many deaths. One of them, for reasons known only to him, poisons the others and runs off with the loot as well as the boss's daughter. The boss orders the others to go after them and bring back the diamonds and his daughter alive, but as for the man, "bring him back dead."

A woman scorned. A witch out for revenge. A small town not ready for what's coming.