When Drake and Josh accidentally send their little sister Megan on a plane to L.A., they soon find themselves in the middle of a dangerous situation.

When band members are stranded on a country road, excitement of their first tour is diminished by the horrors of a science experiment gone awry. Their pig-human hybrid mutant captors have many horrors in store but true revulsion does not descend until daylight when the extent of their work is revealed.