Buff and Cliff star in an animated series. When the series is suddenly dropped and they are no longer animated, they wake up with a set up in each their action figure on the artist's desk. From here begins a hard journey of realization for the two former stars, who are slowly beginning to realize that their entire lives have been constructed.

A treatise of the human animal no. 38: HEARTACHE is an absurd depiction of the human being and its eternal tendency to have its heart broken. In eight standalone chapters, we meet the patients at the now closed Sanatorium for Heartache, in their assiduous attempt to cure themselves of this terrible disease. Meanwhile, on Antarctica, we join the penguin Edgar on an epic journey, as he traverses snowy plains and stormy mountains in an attempt to once again be reunited with the love of his life.

Ivon, a well-known queer performer, tragically passes away before realizing her dream of Hollywood. Despite being widely loved, Ivon still can't find peace in her soul in life or the afterlife. So when the blood moon looms in the sky, Ivon's soul rises from the grave for one more performance.