In 1985 Mexico City, a catastrophic earthquake buries thousands. A doctor with a dark past, a journalist chasing fame, and a family in distress risk their lives in rescue attempts. Their efforts become chances to change their own lives.

Young twins, Imelda and Luis, live a neglected life with their drug dealing mom and jerk-off drug addict older brother. They only have each other to fulfill their desires: she wants to be a nun and he wants to be a girl, neither of which seems possible.