A possessed piñata, seeking to avenge the savagery that humanity has inflicted on his kind, picks off a group of friends, one by one, in an unending night of terror.

In a small Wisconsin lake town, a poverty-stricken felon contracts Creutzfeldt-Jakob Disease after ingesting diseased venison. As his descent into madness intensifies, he targets a Chicago musician and a mysterious singer, whose dream of recording an album together is threatened by the felon's violent unraveling.

Akira is a high school transfer student with a deteriorating relationship with his father. When he arrives at his new school, he stumbles onto a classmate being bullied. His intervention triggers two new friendships — one with the victim Scott and the other with Elizabeth — the classmate who aids him after he is knocked out. Scott has a worse problem than the bullies — he has not come out at home yet. But Elizabeth may have an even bigger problem: she is a social pariah because she keeps acting as though someone or something is after her. Meanwhile, Akira’s home front situation is going from bad to worse.

A series of events during Ruby's freshman year of college send her on a downward spiral, culminated by the arrival of a glamorous alter ego who begins to live a life of her own.