OMG/HaHaHa opens a window to the lives of several young people in Memphis, TN. A gay teenager's video blog frames the various stories, as he introduces his circle of friends and their troubles from unexpected pregnancy to homophobia, break-ups to dying parents.

The film is about a group of teens who collide with their town's dark past when a prank gone wrong makes them the target of a family of bloodthirsty killers.