White Corridors was based on Yeoman Hospital, a novel by Helen Ashton. Told episodically, the story concentrates on the day-to-day activities in a busy hospital, where research pathologist Neil Marriner (James Donald) conducts experiments in the hopes of curing diseases impervious to penicillin. Marriner is aided in this endeavor by lady surgeon Dr. Sophie Dean (Googie Withers), who happens to be in love with him. After a tragedy occurs for which Marriner holds himself responsible, the film builds steadily to an exciting climax involving a untested -- and potentially dangerous -- serum. The top-rank British supporting cast includes Barry Jones, Moira Lister, Petula Clark, Basil Radford, Dagmar (later Dana) Wynter, Bernard Lee, and, in a minor role, future "Dr. Who" Patrick Troughton.

Barry Reckord adapted his stage play for TV and his brother Lloyd plays the central character – a Jamaican new to London. When he begins a relationship with a white woman, he finds himself in conflict with his mother, who has great expectations for him. The very early intimate portrayal of this interracial relationship broke new ground, and is believed to feature one of the world's first examples of an interracial kiss on TV.