Debbie Wilkins escapes from Hollywood and heads east to Oklahoma City to link up with her older sister Fran after she is released from an insane asylum for her murder spree on the set of "The Bayou Butcher" in Axe to Grind. Soon after their reunion, the two sisters embark on a wild and bloody cross country road trip to evade law enforcement after Debbie does away with her parole officer. Meanwhile, Rikki, the younger sister of Nikki who Debbie dispatched of in the first movie, elicits information from Debbie's old flame Peter Burgess in order to track down Debbie and exact her revenge.

There is a house that has been passed down from generation to generation, but it isn't just any ordinary house. This house is built on the Gates of Hell. This Thanksgiving a group of friends desperate to have a nice holiday together, will discover the truth of what goes on inside. It's the age old saying " what happens inside the house, stays inside the house". The doors are locked, the windows are barred, and something sinister is breaking through the floor. Soon they will realize that this house is one that makes The Amityville House look like a Barbie Dream House. The friends learn that in order to escape, the House must feed......on blood!!!!.