The unit specializes in the investigation of serial murders and is led by Van der Bijl, a former murder and robbery detective who gained fame for his handling of several high-profile cases. Each episode focuses on a serial killer. The main character, Colonel Piet van der Bijl, also known as Die Byl, is loosely modeled on the famous ex-detective Piet Byleveld.

After Darby Harper suffered a near-death experience as a child, she gained the ability to see ghosts. To combat the existential boredom of high school, she runs a side business counseling local spirits in her spare time. When an unexpected occurrence happens between Darby and Capri, the most popular girl at her high school, Darby reluctantly agrees to help her and in the process learns how to fit in with the living world again.

A young transgender woman is faced with the challenge of coming to terms with her identity.