Shaun Murphy, a young surgeon with autism and savant syndrome, relocates from a quiet country life to join a prestigious hospital's surgical unit. Unable to personally connect with those around him, Shaun uses his extraordinary medical gifts to save lives and challenge the skepticism of his colleagues.

Two federal agents from two different continents, and two different mindsets, must work together to investigate when wreckage from a destroyed alien spacecraft has mysterious effects on humankind.

After vanishing without explanation years ago, Danny unexpectedly reunites with her devastated best friend Becca. As Danny reconnects, unsettling details about her past with boyfriend Ben emerge, hinting at a dark truth.