Nick must put aside the bong and rally his crew of stoner friends when their new hipster roommate transforms into a murderous werewolf.

Friends in happy San Luis Obispo are about to lose their jobs so they leap into action; a funny series of selfish lurches which lead to betrayal, an accident, several attempts at pregnancy, and some pithy California soul-searching.

An unmonitored clandestine research project suffers a "technical malfunction" and each of the isolated volunteers must devise an escape plan or face certain death.