Bitten by a neogenetic spider, Peter Parker develops spider-like superpowers. He uses these to fight crime while trying to balance it with the struggles of his personal life.

A plague of locusts strikes the Great Valley, decimating the plants and forcing the dinosaurs to migrate in search of food. When the adults in the herd begin fighting over the scarce resources, young Littlefoot and his friends Petrie, Cera, Ducky and Spike split off from the main group, becoming stranded on an island after their path was destroyed by a tsunami. As they search for a way off the island, they encounter an old acquaintance who may become friend or foe.

Doctor Octavius was a brilliant scientist working on a revolutionary new invention until a laboratory accident fused a set of mechanical arms to his body and turned him into the dreaded supervillain Doctor Octopus. Now Doc Ock seeks his revenge on those who did him wrong, and there are only two men who can put an end to his plan of destruction - Spider-Man or his secret alter-ego, Peter Parker.