Cruz Manuelos, a rough-around-the-edges but passionate young Marine, is recruited to join the CIA's Lioness Engagement Team to help bring down a terrorist organization from within. Joe, the station chief of the Lioness program, is tasked with training, managing and leading her female undercover operatives.

In cases ripped from the headlines, police investigate serious and often deadly crimes, weighing the evidence and questioning the suspects until someone is taken into custody. The district attorney's office then builds a case to convict the perpetrator by proving the person guilty beyond a reasonable doubt. Working together, these expert teams navigate all sides of the complex criminal justice system to make New York a safer place.

Robyn McCall, an enigmatic former CIA operative with a mysterious background, uses her extensive skills to help those with nowhere else to turn.

The detectives of the Organized Crime Control Bureau work to dismantle New York City's most vicious and violent illegal enterprises.

NYPD Detective Danny Reagan takes a job with the Boston PD and is paired with Detective Lena Silver, part of a law enforcement family comprised of District Attorney Mae Silver, Police Superintendent Sarah Silver, rookie cop Jonah Silver and Rev. Edwin Peters. Reagan hopes to reconnect with his son, Sean, in Boston.

Journalist Michael Ausiello embarks on a rollercoaster ride of emotions when Kit Cowan, his partner of 14 years, is diagnosed with terminal cancer.

After being brutally dumped, 17-year-old Sydnie discovers she is pregnant. Seeing this as an opportunity to get her ex back and give her life direction, she decides to keep the baby. She soon realizes that this won’t be the quick fix she had hoped for and finds herself caught in a complicated love triangle and totally lost.

Five surviving members of a cult reunite for a weekend retreat, hoping to find closure. But when prophecies of their former leader start to come true, they question whether he was right all along.