Letterkenny follows Wayne, a good-ol’ country boy in Letterkenny, Ontario trying to protect his homegrown way of life on the farm, against a world that is constantly evolving around him. The residents of Letterkenny belong to one of three groups: Hicks, Skids, and Hockey Players. The three groups are constantly feuding with each other over seemingly trivial matters; often ending with someone getting their ass kicked.

As a last-ditch attempt to save his failing marriage, an actor stages a home invasion during a romantic getaway weekend.

Chloe and Jack travel to Miami for their honeymoon. Amidst the flashy neon and sunny beaches, they decide that a peyote experience will strengthen their marriage. Unbeknownst to them, they've been given a rare and powerful strand that sends them on a psychedelic exploration of love, lust, and carnal desire.