Scientist Dr. Bradford Crane and army general Thalius Slater join forces to fight an almost invisible enemy threatening America; killer bees that have deadly venom and attack without reason. Disaster movie-master Irwin Allen's film contains spectacular special effects, including a train crash caused by the eponymous swarm.

Born from incest, Charlie is a mentally disabled young man living with his family in the rural South. When his Cousin Anna arrives. her presence changes the fragile dynamic of the household, leading to a series of emotional confrontations.