American version of the reality game show which follows a group of HouseGuests living together 24 hours a day in the "Big Brother" house, isolated from the outside world but under constant surveillance with no privacy for three months.

The film, directed by Gregori J. Martin and co-directed by Darnell Williams, features a cast that includes Ilene Kristen, Forbes March, Aiden Turner, David Fumero, Jill Larson and Alex McCord. Manhattanites follows the lives of a group of people in New York City who are faced with life changing circumstances and decisions over a period of several months. The choices they makes have far reaching consequences on not only them but people they do not even know.