Al Bundy is an unsuccessful middle aged shoe salesman with a miserable life and an equally dysfunctional family. He hates his job, his wife is lazy, his son is dysfunctional (especially with women), and his daughter is dim-witted and promiscuous.

Parker Lewis is a teenager who apparently can't lose. He's cool, cute, popular, hip – and seems to get away with anything. That's not to say he's got no problems. His two primary nemeses are school principal Grace Musso, whose goal is getting Parker expelled; and his little sister Shelly, whose sole purpose seems to be tattling on Parker. However, with best friends Mikey and Jerry, Parker takes on the world and makes the best of high school.

The lives of head nurse Rachel Gunn and her co-workers at Little Innocence Hospital in Nebraska, where Rachel is often at odds with egotistical surgeon David Dunkel.

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