Shaun Murphy, a young surgeon with autism and savant syndrome, relocates from a quiet country life to join a prestigious hospital's surgical unit. Unable to personally connect with those around him, Shaun uses his extraordinary medical gifts to save lives and challenge the skepticism of his colleagues.

Dr. Bashir Hamed, a Syrian doctor with battle-tested skills in emergency medicine, makes the difficult decision to flee his country and build a new life in Canada with his younger sister Amira. Bash works to navigate a new environment after earning a coveted residency in the Emergency Department of one of the best hospitals in Toronto, York Memorial.

At a private school where gambling determines social status, a skillful new student with a mysterious past is shaking things up — and betting on revenge.

Frankie gets the chance to leave her foster care home to attend an exclusive Swiss boarding school. However, the opportunity of a lifetime comes at a deadly price when one of her classmates is murdered and everyone is quick to blame her.

Jessica and Karl, loving parents to Rhiannon, who after years of trying to add to their family are elated to adopt Gabby, an 8-year-old orphan born with personal challenges. Their ideas of a perfect family come into question when they discover that Gabby is a troubled little girl, and the family begins to believe things aren’t what they seem. As the unsettling behavior of their “child” worsens and lies are uncovered, cracks in the family dynamic form with Jessica becoming increasingly concerned that adopted daughter Gabby is a threat to their family.

Maisy transfers to her late sister's college to find the truth behind her death, where she uncovers that many of the girls on the cheerleading squad are also webcam girls, but revealing the truth may have deadly consequences.