Detective Charlie Hudson teams up with what he calls his "highly trained law enforcement animal" German Shepherd dog named Rex who he prefers to team up with because he doesn't talk his ear off. Based on the Austrian–Italian series, Kommissar Rex.

A year after the death of his friend and partner Sherlock Holmes at the hands of Moriarty, Dr. John Watson resumes his medical career as the head of a clinic dedicated to treating rare disorders. However, he soon finds that his old life is not done with him yet.

A vivacious aspiring social worker brings together five peculiar strangers to help solve their existential problems but finds herself in way over her head.