In Los Angeles, Beatriz, a young working woman, lives a self-destructive relationship with a heroin addict who is willing to pay any price to cover his need to get high. For his part, in the city of Guadalajara, Alejandro Maldonado, maintains a codependent relationship in a marriage that has exceeded the limit of what is tolerable with his wife Olga; an unsatisfied woman, who eagerly looks for men to satisfy her addiction to sex. When the lives of these characters intersect, an exit to their conflicts is visualized in the search for specialized help.

After the passing of their only parental figure, two estranged brothers are forced to either overcome their individual differences or risk succumbing to them.