By coincidence rather than by design, the Swiss chemist Albert Hofmann makes a sensational discovery in the spring of 1943. He realizes that he is dealing with a powerful molecule that will have an impact that reaches far beyond the scientific world. THE SUBSTANCE is an investigation into our troubled relationship with LSD, told from its beginnings to today.

From 1955 to 1975, the US Army used its own soldiers as human guinea pigs in research involving powerful, mind-altering drugs. Told through exclusive footage and first-hand accounts, this is the true story of one of the darkest chapters in US history.

It is August 1951 and an entire French village goes crazy. People are screaming in the streets and throwing themselves out of windows. 300 people are affected and 7 end up dead. Wild theories start circulating to explain the tragedy. 60 years later declassified documents from the United States reveal that the CIA conducted experiments on unsuspecting citizens.

Short film created for the Department of Defense documents a test, code-named Project DORK, which was intended to determine if an aerosol of the delirium-inducing BZ could incapacitate soldiers at distances of 500–1000 yards.