In a Canadian metropolis, failed actor David shares a place with the bookish Candy, whom he dated before coming out as gay. While David, who now waits tables, pursues an aimless romance with a younger coworker, Candy dabbles in both same-sex and heterosexual affairs. As David and Candy's odd assortment of friends — including a telepathic sex worker and an ill-tempered yuppie — pass in and out of their beds, a serial murder stalks the city's women.

Julia Kerbridge is working hard to get her doctorate. Suddenly, she finds herself the guardian of her young niece, Amanda, after the 7-year-old witnesses her parents' murder and is rendered mute. Julia soon discovers that her dead sister and brother-in-law may have held a secret life. Now, she must risk everything as the killers are still hunting Amanda for her parents' secret.

What happens when you don't remember being on vacation? Neurological medicine resident Elizabeth develops a drug and, unknowingly, ends up going from researcher to guinea pig.