In a small Wisconsin lake town, a poverty-stricken felon contracts Creutzfeldt-Jakob Disease after ingesting diseased venison. As his descent into madness intensifies, he targets a Chicago musician and a mysterious singer, whose dream of recording an album together is threatened by the felon's violent unraveling.

Frank and his longtime group of friends traverse a Saturday night of confronting their own fleeting adolescence as the world around them changes and Frank watches his little sister grow up before his eyes at her senior prom.