William Masters and Virginia Johnson are real-life pioneers of the science of human sexuality. Their research touched off the sexual revolution and took them from a midwestern teaching hospital to the cover of Time magazine and multiple appearances on Johnny Carson's couch. He is a brilliant scientist out of touch with his own feelings, and she is a single working mother ahead of her time. The series chronicles their unusual lives, romance, and unlikely pop culture trajectory.

Alex's dreary life is reignited when he meets Rachel, the woman of his dreams. The only thing that stands in the way of their perfect, serendipitous relationship is that Rachel has recently passed away.