William Masters and Virginia Johnson are real-life pioneers of the science of human sexuality. Their research touched off the sexual revolution and took them from a midwestern teaching hospital to the cover of Time magazine and multiple appearances on Johnny Carson's couch. He is a brilliant scientist out of touch with his own feelings, and she is a single working mother ahead of her time. The series chronicles their unusual lives, romance, and unlikely pop culture trajectory.

The two adult kids of an alcoholic retired Navy Officer, maneuver their way through his funeral preparations and grief, by trying to put his unfinished last beer in the coffin, so he won't get sober in the afterlife.