Bitten by a neogenetic spider, Peter Parker develops spider-like superpowers. He uses these to fight crime while trying to balance it with the struggles of his personal life.

Doctor Octavius was a brilliant scientist working on a revolutionary new invention until a laboratory accident fused a set of mechanical arms to his body and turned him into the dreaded supervillain Doctor Octopus. Now Doc Ock seeks his revenge on those who did him wrong, and there are only two men who can put an end to his plan of destruction - Spider-Man or his secret alter-ego, Peter Parker.