While an empowered and wiser Betty works hard on rebuilding her relationship with her teenage daughter Mila, her relationship with Armando begins to deteriorate, making her question if she made the right decision 20 years ago.

Beatriz Pinzón Solano is a brilliant economist with a master's degree in finance; she has only one flaw: she's ugly. Everything changes when she starts working at Ecomoda, one of the country's largest companies, where she meets and falls in love with Armando Mendoza. This time, life will give her a second chance to prove she can become the most desired and beloved woman in the world.

Diagnosed with a terminal illness, Macarena turns her chronic hypochondria into a quest for authenticity, even as her handsome doctor hides a secret.

Gertrudis and Armida are two young sisters with completely different personalities who learn to support each other after becoming orphans and being taken under the care of their aunt Luzmila, who denies them any kind of love. Between their innocence and their audacity, the two young women plan to escape, but everything goes wrong, they end up separated and thinking that the other one has died. It will take two decades for these two sisters to reunite.

Betty and Armando face new challenges as leaders of Ecomoda, a company in crisis. Between rivalries, betrayals, and the return of the unforgettable "Ugly Quarters," they must balance their family life while fighting to save the company's future.