Dr. Gregory House, a drug-addicted, unconventional, misanthropic medical genius, leads a team of diagnosticians at the fictional Princeton–Plainsboro Teaching Hospital in New Jersey.

Chicagoan Frank Gallagher is the proud single dad of six smart, industrious, independent kids, who without him would be... perhaps better off. When Frank's not at the bar spending what little money they have, he's passed out on the floor. But the kids have found ways to grow up in spite of him. They may not be like any family you know, but they make no apologies for being exactly who they are.

Looking down on her friends and family isn't a way of life for Mary Alice Young... it's a way of death. One day, in her perfect house, in the loveliest of suburbs, Mary Alice ended it all. Now she's taking us into the lives of her family, friends and neighbors, commenting from her elevated P.O.V.

A hedonistic jingle writer's free-wheeling life comes to an abrupt halt when his brother and 10-year-old nephew move into his beach-front house.

The exploits of FBI Special Agents Fox Mulder and Dana Scully who investigate X-Files: marginalized, unsolved cases involving paranormal phenomena. Mulder believes in the existence of aliens and the paranormal while Scully, a skeptic, is assigned to make scientific analyses of Mulder's discoveries that debunk Mulder's work and thus return him to mainstream cases.

Three sisters (Prue, Piper and Phoebe) reunite and unlock their powers to become the Charmed Ones, the most powerful good witches of all time, whose prophesied destiny is to protect innocent lives from evil beings such as demons and warlocks. Each sister possesses unique magical powers that grow and evolve, while they attempt to maintain normal lives in modern day San Francisco.

Pulled to the far side of the galaxy, where the Federation is 75 years away at maximum warp speed, a Starfleet ship must cooperate with Maquis rebels to find a way home.

Into every generation a slayer is born: one girl in all the world, a chosen one. She alone will wield the strength and skill to fight the vampires, demons, and the forces of darkness; to stop the spread of their evil and the swell of their number. She is the Slayer.

A gifted young teen tries to survive life with his dimwitted, dysfunctional family.

Against the vibrant backdrop of a 1960s-inspired, retro-futuristic world, Marvel's First Family is forced to balance their roles as heroes with the strength of their family bond, while defending Earth from a ravenous space god called Galactus and his enigmatic Herald, Silver Surfer.

Babylon 5 is a five-mile long space station located in neutral space. Built by the Earth Alliance in the 2250s, its goal is to maintain peace among the various alien races by providing a sanctuary where grievances and negotiations can be worked out among duly appointed ambassadors. A council made up of representatives from the five major space-faring civilizations - the Earth Alliance, Minbari Federation, Centauri Republic, Narn Regime, and Vorlon Empire - work with the League of Non-Aligned Worlds to keep interstellar relations under control. Aside from its diplomatic function, Babylon 5 also serves as a military post for Earth and a port of call for travelers, traders, businessmen, criminals, and Rangers.

Dr. Mark Sloan is a good-natured, offbeat physician who is called upon to solve murders.

Ryan Atwood, a teen from the wrong side of the tracks, moves in with a wealthy family willing to give him a chance. But Ryan's arrival disturbs the status quo of the affluent, privileged community of Newport Beach, California.

A family man struggles to gain a sense of cultural identity while raising his kids in a predominantly white, upper-middle-class neighborhood.

When Buy More computer geek Chuck Bartowski unwittingly downloads a database of government information and deadly fighting skills into his head, he becomes the CIA's most vital secret. This sets Chuck on a path to become a full-fledged spy.

Drew is an assistant director of personnel in a Cleveland department store and he has been stuck there for ten years. Other than fighting with co-worker Mimi, his hobbies include drinking beer and not being able to get dates. To make a few extra bucks he has a micro-brewery going in his garage with his buddies.

Brothers Brian and Joe Hackett attempt to run an airline on the New England island of Nantucket while surrounded by their various wacky friends and employees.

When petty criminal Earl Hickey wins the lottery, he sets off on a quest to repair his questionable karma.

A long-running dramedy centering on the Winslow family, a middle-class African American family living in Chicago, and their pesky next-door neighbor, ultra-nerd Steve Urkel. A spin-off of Perfect Strangers.

While attending a Hollywood premiere with a famous action star, a crazed fan pulls a gun—but her movie hunk turns into a coward, and it's Vallery who becomes the hero. Suddenly, she's thrown into a world of action and danger as owner of a Hollywood protection agency, Vallery Irons Protection (V.I.P.), taking risks to protect others at a price few are willing to pay.