The series tells the story of two fifteen-year-old twin brothers, Pedro and Bianca, being white and black, which made them known in the region where they live. Pedro & Bianca shows the class C teenagers who recently entered the first year of high school, at the Piquerobi State School (Alberto Torres State School), a public school in São Paulo, and follows the daily lives of both at school, where they face common problems that teenagers experience.

Three girls are invited to participate in a music festival in their summer. However, they discover that they are in summer school, so they need to find a way to go to the musical festival without their parents finding out.

Neusa Sueli is a trans actress who finds in Vado's bathroom a wonder that could lead them finally produce their play. As they expose their discovery, the other writers confront Neusa and Vado about the authenticity of their story.