Set in 15th century Italy at the height of the Renaissance, The Borgias chronicles the corrupt rise of patriarch Rodrigo Borgia to the papacy, where he proceeds to commit every sin in the book to amass and retain power, influence and enormous wealth for himself and his family.

The film is based on a story by Corbijn and Bono, and includes several of the characters Bono created for the album. The plot focuses on a Parisian motorcycle officer, played by Saïd Taghmaoui; the character has become disillusioned with his life and the conflict between immigrants and the police in the city, causing him to leave to see his girlfriend in Tripoli.