Quiet and unassuming church organist Jenny Moran is depressed with her marriage to working-class Matt and leaves him. Jenny begins an affair with the manipulative and charming Dr. Stephen Carrow, who is also deacon of her church and a married man. Someone kills Carrow's wife after she learns of the affair between Jenny and her husband. The murderer is caught and confesses, but that confession leads to new lies which tear apart Jenny Moran's life.

Middleton prepares for its bicentennial, and Grey House is to be the party venue. Good witch Cassie is remodeling it as B&B. her first and only guest, Nick Chasen, claims to be a distant relative. He produces papers to prove he's the heir of the builder, colonial era captain Hamblin, while the Grey lady was his mistress and stole it. Police chief and lover Jake Russell goes all the way to motivate her to fight and disprove the claim before she's effectively disowned. Brandon is dared to pass a rascals-initiation by local brat Steve and Duke. George's gardening skills lead to romance.

Builder Robert is visiting his ailing wife in a nursing home and is having problems getting a taxi home due to an intense snow storm. One of the doctors, Katherine offers him a lift home however their car gets stuck and they have to spend the night in an empty cabin nearby. They talk and bond, but afterwards seem to have difficulty beginning a relationship.

The true story of three sisters who unite in the face of adversity when one of them is diagnosed with ALS, also known as Lou Gehrig's Disease.