Every five years in a different part of the world, a select wealthy few are invited to participate in a game. The difference between this and any other game are the stakes: human lives. Gortari, the great business mogul and head of the organization, selects individuals with skills in combat and recruits them into the game against their will. For those who observe making their bets, it's an afternoon of entertainment; for the players, it's a bloodthirsty fight to the death where anyone can be the cat or the mouse. Aurelio, one of the strongest players, survived the last game five years before. It will be up to him to become once again a prisoner of the game, or rise up and destroy the organization from its very foundations as he fights against time and the other 14 players.

Adrián is a sex worker and a member of the mafia of a betting house, where El Cangrejo is the leader.

The most important hit man in the plaza fakes his death to get out of that world of drugs and death, but a person important to him will make him return to the world he thought he was leaving behind.

Gerardo Casasola, "El Estudiante", now has the mission of rescuing his sister.