In 1930s Oklahoma amid the region's horrific dust storms, a woman is convinced that a sinister presence is threatening her family.

In the summer of 1859, a widowed physician reluctantly agrees to take a recently freed slave and her mysterious Caucasian daughter on a five-day journey through the bloody West to find a distant town's Faith Healer. The woman believes her daughter is possessed. The doctor believes she simply carries The Sickness. Either way the fact remains that every living thing the girl touches mysteriously dies.

Clea, a newly pregnant thirty-something struggling to get her life together, who reluctantly joins her tightly wound sister Frannie on a road trip to visit her estranged parents. When Clea brings along her free-spirited friend Abel to lighten the mood, clashing personalities and a string of chaotic detours force the trio to confront old wounds and buried truths on a journey that becomes an unexpected reckoning.