Steve McGarrett returns home to Oahu, in order to find his father's killer. The governor offers him the chance to run his own task force (Five-0). Steve's team is joined by Chin Ho Kelly, Danny "Danno" Williams, and Kono Kalakaua.

When two weddings are ruined by both the bride and groom getting left at the altar, they still decide to take their honeymoons, not knowing they are heading to the same resort in Hawaii.

Lily, a young doctor, wakes up from a car accident and discovers she is living a completely different life. Now married to her boyfriend’s rival, Dr. Mitch Kayne, and a mother to a 5-year-old son, she has an established life she remembers nothing about. Everyone around her denies that her boyfriend Neil ever existed. As Lily begins to doubt her own sanity, memories of Neil resurface, causing her to encounter unexplainable incidents. While desperately searching for the truth of her past life, she questions her entire existence; but in the end, she discovers the meaning of true love.