Alice, the only relatively normal member of the eccentric Sycamore family, falls in love with Tony Kirby, but his wealthy banker father and snobbish mother strongly disapprove of the match. When the Kirbys are invited to dinner to become better acquainted with their future in-laws, things don't turn out the way Alice had hoped.

After healing the leg of the murderer John Wilkes Booth — responsible for the assassination of President Abraham Lincoln — Dr. Samuel A. Mudd, considered part of the atrocious conspiracy, is sentenced to life imprisonment and sent to the sinister Shark Island Prison.

A visit to a Hollywood nightclub, featuring caricatures of, among others, Walter Winchell, Hugh Herbert, W.C. Fields, Katharine Hepburn, Ned Sparks, Johnny Weissmuller, Lupe Velez, John Barrymore, Harpo Marx, George Arliss, Mae West, Stan Laurel, Oliver Hardy, Clark Gable, Edna May Oliver, Gary Cooper, The Dionne Quintuplets, Groucho Marx, Helen Morgan, Wallace Beery, Edward G. Robinson and George Raft.

A cow and her calf are bedding down for the night. The calf is frightened by a shadow, until it's revealed to be a jackrabbit. He follows the rabbit deep into the woods. Neither of them notices the wolf following.

The gang is sitting around their campsite when a mosquito spoils their fun. And then he gets hundreds of his friends and they really cause trouble. Horace squirts some with molasses, which helps a bit. Everyone retreats to the tent, where they still get stung but can fight back a bit, eventually trapping all the mosquitoes in a pair of bloomers and sending them on their way.

A hound chases a young rabbit, ultimately cornering him against a tree. But the dog doesn't want to eat the rabbit, just make friends. The bunny takes his new friend (who he names Sniffy) to where the rest of the rabbits are playing football and, after introductions, they join in. Soon a fox happens along.