The future-fantasy world of Remnant is filled with ravenous monsters, treacherous terrain, and more villains than you can shake a sniper-scythe at. Fortunately, Beacon Academy is training Huntsmen and Huntresses to battle the evils of the world, and Ruby, Weiss, Blake, and Yang are ready for their first day of class.

In San Francisco, Jill Valentine is dealing with a zombie outbreak and a new T-Virus, Leon Kennedy is on the trail of a kidnapped DARPA scientist, and Claire Redfield is investigating a monstrous fish that is killing whales in the bay. Joined by Chris Redfield and Rebecca Chambers, they discover the trail of clues from their separate cases all converge on the same location, Alcatraz Island, where a new evil has taken residence and awaits their arrival.

Three kids, Max, Neil and Nikki, spent the summer vacation at a dysfunctional campsite called 'Camp Campbell' which is currently in the hands the camp counselors, the overly cheerful David and the less optimistic Gwen.

In Tokyo, there is a place called Velude Way. It is a district notorious for its performers and theatrical groups. Izumi Tachibana, who was previously a stage actress, arrives with a letter that reads, "Full of debt! Zero customers! Only one actor!" It describes the current state of the once-popular theater group Mankai Company. Her task is to rebuild the company to its former glory as the new owner and chief director.