The Cheating Game revolves around Hope (Julie Anne San Jose) and Miguel (Rayver Cruz). Hope is an NGO worker who finds out her fiance is cheating on her. She calls off the engagement, quits her job, and tries to start over. She then meets Miguel (Rayver Cruz), a self-made businessman who has also experienced getting cheated on. As they become closer, secrets from their past start to unravel and they discover they have more in common than just being cheated on.

When a rich kid slacker meets a working class breadwinner, the two form an unlikely friendship in spite of their differences. With the pandemic and society bearing down on them, they fight back by throwing the biggest illegal rave the lockdown has ever seen.