Slade Collins and The Tree Of Life is an adventure film that explores ancient Iroquois folklore. The story follows a relic hunter named Slade Collins who is employed by a museum caretaker to find Dr. Winters, a renowned anthropologist who has gone missing. Dr. Winters was researching The Tree Of Life in an attempt to uncover its secrets. In Iroquois myth, The Tree Of Life is believed to be directly tied to the story of Creation. Through an unfortunate event, Slade teams up with Sill Winters, Dr. Winter's daughter who is also searching for her father. Together, they set out to find the Tree Of Life and the doctor. Unfortunately for them, they are not the only ones searching for The Tree Of Life. The nefarious Reverend Wendell Cobb and his associate, the ruthless mercenary named Czar are also searching for it. Together they set out to bring about the end of the world as we know it.

Cassia, a young naïve girl who is pure of heart, has been chosen to be the last Vestal of Light and must set off on a quest to seal away the darkness.