The series tells stories of people who sought psychotherapeutic help from Dr. Manov, an internationally recognized psychoanalyst, and his wife, Dr. Yasenova, a specialist in child and adolescent psychology. Each series parallelly follows what is happening in the two offices, as well as the relationship between the two therapists.

At the beginning of the 19th century, the plague swept through the Bulgarian lands. Chorbaji Yurdan and his son Yono return from Hadzhilak and find the villagers starving and scared. The Black Plague brings to the fore the greatest human fears and atavistic survival instincts.