Harley Quinn has finally broken things off once and for all with the Joker. Now, she's trying to make it on her own as the criminal Queenpin of Gotham City, with help from Poison Ivy and a ragtag crew of DC castoffs.

Jaded 74-year-old reptile Leo has been stuck in the same Florida classroom for decades with his terrarium-mate turtle. When he learns he only has one year left to live, he plans to escape to experience life on the outside but instead gets caught up in the problems of his anxious students — including an impossibly mean substitute teacher.

Thelma dreams of being a glamorous unicorn. Then in a rare pink and glitter-filled moment of fate, Thelma's wish comes true. She rises to instant international stardom, but at an unexpected cost. After a while, Thelma realizes that she was happier as her ordinary, sparkle-free self. So she ditches her horn, scrubs off her sparkles, and returns home, where her best friend is waiting for her with a hug.

Van, the brave son of a tooth fairy leader, meets the goblins girl Gemma on his first mission. Despite the myths about ancient disputes between fairies and goblins, they share common values. When the greedy Spider Queen threatens both tribes, they must work together.