Gru and Lucy and their girls—Margo, Edith and Agnes—welcome a new member to the Gru family, Gru Jr., who is intent on tormenting his dad. Gru also faces a new nemesis in Maxime Le Mal and his femme fatale girlfriend Valentina, forcing the family to go on the run.

Remember BUDDY—the bright orange unicorn and star of that classic childrens' television show who brought joy and life lessons into your living room? Inside the colorful world of "It's Buddy!", a group of children spend their days singing, dancing, and helping Buddy spread happiness. But when one child refuses to play along, Buddy is not pleased and cracks begin to appear in this seemingly perfect world.

The Minions will try anything to help Agnes overcome her fear of the dark, even if it involves going into outer space.