Italy, 1997. When Clara and Irène, both 17, meet they are nothing like each other but get on marvellously well. They run away together to a faraway island off the coast of Sicily to live their summer freely, and to hide from a reality they want to forget.

These are the years of the First World War and Dr. Stefano Zorzi spends his days in the Exemption Clinic in a large city of Northern Italy, where he not only takes care of soldiers who arrive from the massacre of the front, but also he fights simulation and self-harm of those who hope to be dispensed, by sending them before the Military Court. If Stefano, in fact, does his utmost to heal soldiers and send them back to fight, Dr. Giulio Farradio makes them ill, or helps them to self-injure seriously enough to be exonerated. The two doctors, who went to university together and were great friends, they not only (secretly) challenge each other on a professional level, but also on the sentimental one: they are both linked to Anna, a courageous nurse with a strong character. But when the great ‘Spanish’ fever epidemic arrived in 1918, the time for love, politics and science ends up getting confused dangerously...