The film follows intrepid reporters Nicholas Kristof and Sheryl WuDunn and actor/advocates Malin Akerman, Mia Farrow, Ronan Farrow, Jennifer Garner, Regina Hall, Ashley Judd, Blake Lively, Eva Longoria, and Alfre Woodard to Colombia, Haiti, Kenya, and throughout the United States as they uncover the harshest forms of gender-based oppression and human rights violations, as well as the effective solutions being implemented to combat them.

Pulitzer Prize-winning journalists Nicholas Kristof and Sheryl WuDunn explore the causes and costs of addiction, poverty and incarceration plaguing America, from the inner city to small towns like Kristof's hometown of Yamhill, Oregon. While pockets of empathy and aid exist, are they enough to rescue the thousands of Americans in despair, for whom the American Dream of self-reliance is impossibly out of reach?