The Five Brothers follows the Juthathep brothers in the 1960s, raised by their grandmothers after their parents’ tragic death. Born into nobility, they are expected to embody honor, protect the weak, and—most importantly—marry well. But their lives become more complicated when a sacred promise binds one of them to marry a lady of the Dhevaprom family, and breaking it would bring great dishonor.

A car crash on a bridge causes Keng and Prae a big trouble in their lives. When they regain consciousness, they realize that their souls have switched bodies. Things get even worse when both realize the unique problems of having a body of the opposite sex.