When a group of old college friends reunite at a remote lakeside cabin, they quickly realize something is wrong—the forest is too quiet, and the local wildlife is missing. Soon, they're hunted by a swarm of mutated, flesh-eating otters infected by toxic waste from a nearby chemical spill. As the blood-soaked chaos unfolds, friendships fracture and survival instincts kick in. With no way to call for help, the group must fight back using whatever weapons they can find—including a chainsaw and a whole lot of rage. But just when they think it's over, the infection reveals it may have already claimed one of their own.

A group of college students host a midnight grindhouse film festival. They discover a cursed arthouse horror called The Creeping Chaos. In classic horror fashion, they screen the film, unleashing absolute mayhem.

After narrowly escaping an armed robbery, Travis Wilkes invites the drifter who saved him back to the isolated home where he and his girlfriend reside, not realizing that he's opened the door to a night of terror and brutal revenge.