Scott Gamble waits anxiously in the Emergency Room to hear the status of his little sister. After overhearing the nursing staff whispering about the superstitions surrounding Room 566, where his sister is to be placed overnight, he must get her out of the room before it's too late.

A brother and sister struggle with his health, an actress tries to stop prostitution, and an immigrant looks for a future as his girlfriend slips into insanity. A tragic accident brings them all together and reveals how they are connected.