Healthcare reform in Hong Kong is a controversial topic. The government plans to privatize public hospitals and raise funds to maintain operations. Marshall Paxton, a leading public hospital, has become a pilot for reform. This drama focuses on the everyday workings of medical professionals and the politics behind the healthcare industry in Hong Kong.

Dr. Ko Lap-yan heads a team of senior psychiatrists and residents at the Yan Wo Hospital in Hong Kong. Most episodes revolve around the team diagnosing patients. With a specialty at diagnosing criminals, Ko also has close ties with the Serious Crime Unit of the Hong Kong Police Force, a unit headed by Senior Inspector Chung Kwon-ban. The second series sees Ko's resignation from the Yan Wo Hospital; he is later transferred to a new psychiatric department, the Forensics Psychiatry Department, of Bok On Hospital, where he formally diagnoses criminals.

As the co-founder of the Chinese law firm Donald & Co., Charles Cheuk, has been a chairman of its committee for many years. Though he had promised his managing partner KC Lau that he would step down, Charles hires the money-minded lawyer Kent Cheung as a new partner for the firm, hoping that he would be able to counterbalance KC’s growing obsession for authority.

In a high-stakes corruption case, ICAC Principal Investigator Kong Kin-chau edges closer to the truth within a listed company. Chief Investigator Szeto Kai-man and Assistant Investigator Ting Sum go undercover as a father-daughter duo to gather evidence against a construction firm, while Firearms Team member Chui Ho-nam and Assistant Investigator Chung Hau-ling help secure crucial intel. Meanwhile, Senior Investigator Ng Hok-bun exposes corruption within the prison system. Despite differing views and setbacks, the team remains steadfast in pursuing justice in the secondary school engineering scandal.

A successful PR executive accustomed to managing other people's crises must confront her own family problems when her daughter becomes embroiled in a scandal and her estranged mother suddenly returns home.